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Filip Van der Gucht - ProCepT Belgium
Title
Spray Drying / Congealing / Prilling, an instant Process to engineer a particle
Abstract
Spray Drying, is drying process nr 1 in the world, thanks to its speed of drying and the capabilities to engineer a particle to size, shape and function. This lecture introduces the Spray Drying / Congealing / Prilling process technology and capabilities in particle engineering.
Bio
Filip Van der Gucht has a Master in Chemical Engineering BioTechnology and is Business Development Director and co-founder of ProCepT. Filip has built up 20 years hands-on process knowhow in drying, agglomeration, mixing and coating technologies. He is involved in several contract development and scale-up projects for third parties.
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Guy Van den Mooter - University of Leuven Belgium
Title
Particle agglomeration
Abstract
Size enlargement of particles through agglomeration processes is one of the important unit operations during the development of pharmaceutical dosage forms like tablets or capsules. Agglomeration changes the bulk properties of solids, like flow properties, reduced sticking tendency and reduced dust formation. In a first part of this presentation, the physical mechanisms responsible for particle agglomeration will discussed. The second part will give an overview of agglomeration technologies used during pharmaceutical development like wet and dry granulation, extrusion, spray drying and compression-compaction.
Bio
Prof. Guy Van den Mooter studied pharmacy and industrial pharmacy at the KU Leuven and received his PhD from the same university in 1994. He worked as scientist in the department of pharmaceutical development at Janssen Pharmaceutica (Belgium) until 1996. From 1997 until 1999 he was a post-doctoral researcher in the laboratory for Pharmacotechnology and Biopharmacy (KU Leuven). In 1999 he was appointed assistant-professor and in 2009 full professor at the KU Leuven. His main research interests are the physical chemistry of solid dispersions, formulation strategies for poorly soluble drugs like solid dispersions, nanoparticles, and mesoporous silica, polymorphism of drugs and thermal analysis. He teaches courses of pharmaceutical technology and physical chemistry of drugs in undergraduate and graduate programs. He is the coordinator of the master program in industrial pharmacy. So far, he has (co)authored more than 200 peer reviewed papers.
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Hans van der Meer - Sympatec Benelux
Title
Introduction in Laserdiffraction and applications.
Abstract
Theorie of laserdiffraction. Dispersion of particles, optics for laser diffraction and evaluation methods. Applications in Food and Pharmaceutics.
Bio
Hans van der Meer is business unit manager for Sympatec in the BENELUX. After a study of Analytcal Chemistry at the Hogere Laboratorium School Breda, I started in 1972 at several laboratories in the Food industrie. In 1985 I switched to the sales of laboratory instruments with the specialisation in particle sizing. In 1994 I started Sympatecs Office in Etten-Leur for the BENELUX.
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Anne Haaije de Boer - University of Groningen The Netherlands
Title
Preparation and laser diffraction characterisation of inhalation powders.
Abstract
Inhaled aerosols need to have an aerodynamic particle size distribution within the very narrow range from 1 to 5 micron. This size distribution can be obtained with different techniques including fluid energy milling, spray drying and (anti-solvent) precipitation. Which technique is preferred may depend on the dose weight, the physico-chemical properties of the powder obtained and the inhaler used for aerosol delivery to the respiratory tract. For development of dry powder inhalation systems, laser diffraction technique is a fast, accurate and reliable tool, as it enables to study the dispersion efficiency of the powder into a suitable aerosol with the dry powder inhaler designed or selected for this purpose
Bio
Anne Haaije de Boer is a process engineer who started his career at the University of Groningen for the Department of Pharmaceutical Technology and Biopharmacy in 1973. In 1990 he became the founder and leader of the inhalation group of the department which focuses on understanding the mechanisms of particle-particle interaction in dry powder formulations for inhalation, the development of new techniques for aerosol characterisation and dry powder inhaler (DPI) concept development. His group has collaborations with several universities and (pharmaceutical) industries in Europe, Australia and the USA and developed the basic concepts for the marketed Novolizer (Meda) and Genuair (AstraZeneca) DPIs for delivery of anti asthma and COPD drugs and the Twincer and Cyclops DPIs for the delivery of high dose antibiotics to patients with infectious lung diseases. The Twincer and Cyclops will be taken into production in 2014 and 2015 respectively by a local company. Anne Haaije de Boer holds several patents and has more than 90 (co-)authored peer reviewed papers.
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Max Hollek - Sympatec Germany
Title
Introduction Dynamic Image Analysis and applications.
Abstract
Particle Size Shape Analysis from static image analysis to Dynamic Image Analysis . Optics and measurement , statistics and evaluation modes. Applications.
Bio
Max Hollek studied mechanical engineering at the technical university of Clausthal-Zellerfeld. He received his engineering diploma in June 2000. After that he worked as a project engineer for several years before moving into sales management. He covers particle sizing projects in various fields including the pharmaceutical-, food-, building material-, and chemical- industries as well as research and development directly within individual companies or in general at universities and research centers.
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Geert Verreck - Janssen R&D Belgium
Title
Particle Engineering in Pharma, Industrial Case Studies
Abstract
Pharmaceutical oral solid dose manufacturing involves the engineering of particles and granulates using conventional and enabling technology platforms. Particle engineering plays a critical role in determining the final drug product characteristics and biopharmaceutical performance of the active pharmaceutical ingredient (API). The focus of the presentation will be on enabling technologies such as spray drying, hot melt extrusion and bead coating to increase the dissolution rate to enhance bioavailability or to modify the release of the API. Also downsizing to the nano-domain particle size will be discussed using technologies such as high energy milling and electrostatic spinning. Real case studies will be presented from early and late development examples as well as commercial manufacturing.
Bio
Dr. Geert Verreck is a Scientific Director and Fellow in Drug Product Development at Janssen R&D in Beerse, Belgium. His expertise is in the area of oral solid development, from preformulation to early and late development as well as transfer to commercial manufacturing. Dr. Verreck specifically has expertise in enabling technology platforms such as hot melt extrusion, spray drying, bead coating, supercritical fluid technology and nanotechnology (particle size reduction via milling and electrostatic spinning). He started working for J&J in 1995 after graduating as a chemical engineer. In 2005 he received his Ph.D. in Pharmaceutical Sciences at the Catholic University of Leuven, Belgium. He has published 34 peer reviewed journal articles as author or co-author and holds 8 patents in the area of solid dispersions. Dr. Verreck also presented approximately 85 meeting abstracts and delivered approximately 50 oral presentations. He is also the recipient or co-recipient of various recognitions including the ISASF (International Society for the Advancement of Supercritical Fluids) PhD thesis award (2005), the J&J Philip B. Hofmann Award (2006), the J&J Business Excellence Award (2008), the J&J Standards of Leadership Award (2009).
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Gabriël Meesters - DSM The Netherlands
Title
Continuous Granulation
Abstract
How can we come from a dry powder to a granulate. What parameters are important and how can we describe a model for this process. Controlling of a continuous agglomeration process by measurement of the particle size.
Bio
September 1987 - December 1991: Ph.D. and Scientific member of the Delft University of Technology, The Netherlands
February 1992 - June 1995: Scientist Formulations at Gist-brocades, The Netherlands, Bio-Specialties Division, Product Application and Formulations (R&D/BSD/PAF)
June 1995-December 1996: Genencor International BV., USA-based company, Formulations scientist; Enzymes for cleaning products, R&D in the Netherlands.
January 1997-present: Science Manager for the Food Specialties Division of Royal Gist-brocades NV, for Recovery and Formulations. Principle Scientist particle Technology, senior scientist formulations
July 1997- present; part time assistant professorship at the Delft University of Technology, Department of Chemical Engineering, section Particle Technology
Executive member of the Dutch and Belgium Aerosol Society (Aug. 1993-present )
From Aug-1997-2003 secretary of the Dutch and Belgium Aerosol Society
Lecturer: Post-academic course on Powders and Agglomerates. (1994- 2012).
Executive member of the European Federation of Chemical Engineers: working party Agglomeration
Member of EHEDG (European Hygienic Equipment Design Group), sub group Dry Materials Handling, 1998-present
Examiner at the The Hague University of Applied Sciences (2010-present) |
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Wim Pries - AkzoNobel Powder Technology The Netherlands
Title
Particle characterization is more than only particle size measurement
Abstract
Particle characterization is a basis for process design, process understanding and product quality. First phase for characterization is representative sampling. The sample size depends on several factors like batch size, particle size distribution, expected content of ingredient, required accuracy, et cetera. Complicating factor is that dry, granular materials are sensitive to segregation which is the major cause for sampling and characterization errors.The second phase is sample splitting/dividing the representative sample to the size required for measuring the characteristics. The third phase is to choose the proper characteristic(s) to characterize the process (steps) and/or product quality. This lecture reviews different sampling and splitting techniques for dry granular materials. Also a selection will be given of methods for measuring characteristics of individual particles and of a larger number of particles
Bio
Wim Pries finished Chemical Technology study at HTS Groningen in 1972. From 1974 – 1976 he was assistant manager in a plant Quality Laboratory of Enka Glanzstoff in Emmen. In 1976 he joined the Powder Technology group at Akzo Zout Chemie Research in Hengelo in. He contributed in projects as a researcher and as plant support technologist in the powder technology field for different products e.g. salt, soda ash, sodium mono chloric acetic acid, mono chloric acetic acid and CMC. He has a broad experience as researcher in characterizing particles and powders as well as technologist in powder unit operations like compaction, milling, grinding, separation, transport, storage, et cetera. After the centralization of the AkzoNobel Chemicals Powder Technology departments in 1996 in Deventer he is powder technology researcher, - specialist and - consultant in this department.
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